Duodenum starts where stomach ends. It is first part of the small intestine and ends in the jejunum. The draining channel to drain bile from liver also ends in duodenum – called as common bile duct. Cancer arising from duodenum is duodenal cancer. It is a very rare kind of cancer. Less than one percent of all cancers arise from duodenum. This cancer can occur in anybody, however, it is most commonly seen above 60 years of age.

Some risk factors increasing the likelihood for this cancer are:

1. Age
   As already mentioned, these cancers are most commonly seen above 60 years i.e. increasing incidence with increasing age.
2. Inflammatory bowel disease
   These are the disorders of the gut. They are of two main types, Ulcerative colitis, and Crohn’s disease. They cause chronic inflammation in the gut and have a waxing waning course. They predispose to cancers of both the small intestine and large intestine.
3. Some kinds of genetic disorders or hereditary syndromes 
   Lynch syndrome, Peutz Jeghers syndrome. Families and persons suffering from these syndromes have an occurrence of cancer at a younger age and more than one kind of cancer can be seen.
4. Alcohol intake
   Alcohol also predisposes to cancers of the small intestine and large intestine.
5. Diet where red meat and proceeded meat intake is high. 

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