Many handmade crafts websites have successfully reached their audience and are doing their business in a better way. You have 2 common ways of selling handmade items online

Get Connected With Any Reputed eCommerce Marketplace or if you are more specific about this business then you can put all your efforts into building your own handmade ecommerce platform and reaching your target audience. You can be a single seller for your platform or can connect multiple sellers to your marketplace and can make it a multi vendor platform.